Liver satire delivers

RNAi Delivers Insights into Liver Cancer

Of the myriad alterations in gene copy number found in cancer cells, which alterations are critical for the cancer phenotype? In this issue of Cell, Zender et al. (2008) describe an integrative genomics approach to identify new tumor suppressor genes involved in hepatocellular carcinoma.

Satire for Dummies, Ver. 2.0

Subversive Satire: the Glasgow Verses

The Glasgow Verses constitutes a formal anomaly in terms of genesis, appearance and meaning. Discovered only in 1995, the verses are part of a larger text, the so-called Hunter Codex, a manuscript MaruliÊ wrote and dedicated to his friend Dmine PapaliÊ. Closer investigation revealed that this collection of poems had been entirely overlooked by traditional scholarship, and that it was neither ch...

Kinesin Delivers

What is it about movement in cells that commands our atten-tion? What biologist has not enjoyed turning a microscope on a cell, almost any cell, really, and watching all the commo-tion? When vesicles, mitochondria, chloroplasts, nuclei, or chromosomes move, we are being treated to an elegant, easily observable manifestation of molecular events. Decades of effort to understand intracellular move...

Value Flow Graph Analysis with SATIrE

This work discusses implementation of partial redundancy elimination using the value flow graph, a syntactic program representation modeling semantic equivalences. It allows the combination of simple syntactic partial redundancy elimination with a powerful semantic analysis. This yields an optimization that is computationally optimal and simpler than traditional semantic methods. A source-to-so...